• How Cymbalta Works
• What to Expect
• Important Safety Information
• Side Effects
• Commonly Asked Questions About Cymbalta
• Contact Us
• About Lilly

How Cymbalta Works

Cymbalta is FDA-approved for fibromyalgia

Cymbalta is approved by the FDA for the management of fibromyalgia.more

Cymbalta offers relief from symptoms of depression, generalized anxiety disorder (GAD), diabetic nerve pain (DNP), and fibromyalgia. Over 9 million patients in the United States have been treated with Cymbalta. Cymbalta is not a narcotic.

While the mechanism of action for Cymbalta is not fully known, its effects on depression, GAD, DNP, and fibromyalgia may be due to increasing the activity of two naturally occurring substances in the central nervous system, serotonin and norepinephrine. Cymbalta is in a class of medications called selective SNRIs (serotonin and norepinephrine reuptake inhibitors), and is FDA-approved for the treatment of depression and GAD and the management of DNP and fibromyalgia.

SNRIs are a class of medications that are thought to relieve symptoms by affecting the levels of serotonin and norepinephrine in the brain and in the spinal cord. By reducing the absorption of serotonin and norepinephrine into cells, SNRIs increase the levels of these two substances.

Learn how naturally occurring substances in the brain and spinal cord may affect mood and pain

You can also read the full Prescribing Information for details about Cymbalta.